The Division of Gastroenterology at Washington University School of Medicine performs cutting-edge molecular and translational research.

We have a diverse research base with physician-scientists (MD and MD/PhD) and PhD scientists conducting basic investigation into the molecular regulation of development, nutrient absorption, colon carcinogenesis, immune tolerance and inflammation and repair.

In addition, we conduct a range of active translational research, including novel therapies for inflammatory bowel disease, obesity and energy metabolism, hepatic steatosis, hepatitis C and topographic manometric assessment of esophageal motility.

Principal InvestigatorResearch Interests
Matthew Ciorba, MDInflammatory Bowel Disease (laboratory, clinical, and translational clinical trials)
Colorectal Cancer (laboratory and translational clinical trials)
Intestinal SARS-CoV-2 / COVID-19 (laboratory and clinical)
Additional Keywords: Organoids, probiotics, radiation, murine models, tryptophan metabolism, Crohn’s, colitis
Visit The Ciorba Lab site
Nicholas Davidson, MDThe molecular genetics of lipid transport and in the post-transcriptional regulation of gene expression; Lipid storage diseases and defects in macronutrient absorption; The molecular genetics of colorectal cancer
Brian Dieckgraefe, MD, PhDThe study of the cellular signaling pathways and mediators used to sense and respond to epithelial injury; The identification of proximate events in the development of Crohn’s disease
Dayna S. Early, MDUnderstanding barriers to colorectal cancer screening; The effect of insulin resistance on the development of colorectal neoplasia; The role of selenium on the development of colorectal neoplasia; Diagnosis of gastrointestinal cancers
Marc Levin, MDThe molecular basis of the small intestinal adaptive response following loss of small bowel surface area; Nutrient modulation of the small intestinal adaptive response; The role of retinoids and cellular retinol binding proteins in small intestinal adaptation
Rodney Newberry, MDIntestinal inflammatory diseases; The incidence of celiac disease among persons with osteoporosis
Deborah Rubin, MDIdentifying the molecular mechanisms underlying intestinal epithelial cell proliferation and differentiation; The role of epithelial mesenchymal interactions in inducing the normal morphogenesis and differentiation of the gut mucosa