Stewart (Siyan) Cao is a spectacular physician-scientist and an Assistant Professor in the Division of Gastroenterology. His PhD training on the unfolded protein response showed that endoplasmic reticulum (ER) stress is important in intestinal homeostasis and mouse models of IBD. Stewart has continued to pioneer projects on cellular stress response in innate lymphoid cells (ILCs) in intestinal inflammation, developing novel mouse models and identifying ILC-related biomarkers in patients with IBD. Stewart has defined single-cell signatures of Crohn’s disease of the ileoanal pouch (Cao et al., 2024 Gastroenterology) and perianal Crohn’s disease (J. Clin Invest, 2025). He has presented his work at several international conferences and was an invited speaker in 2024 at Johns Hopkins University and University of North Carolina. Stewart has been actively involved in peer-review and was recently invited to join the scientific advisory committee of Crohn’s and Colitis Foundation.
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