Gary R. Zuckerman, DO


Emeritus Associate Professor of Medicine


Dr. Zuckerman joined the Gastroenterology Division in 1975 and has a principal role in the clinical program at the Digestive Disease Clinical Center of Barnes Hospital. Dr. Zuckerman received his D.O. from the University for Health Sciences, College of Osteopathic Medicine, in Kansas City and completed his Internal Medicine postgraduate training at Tulsa Regional Medical Center (Oklahoma). He subsequently trained as a fellow in gastroenterology at Washington University School of Medicine and then returned to the University of Health Sciences as a gastroenterology faculty member. Following a brief appointment at Saint Louis University School of Medicine, he joined this division to spearhead the clinical program. His primary research interests include: (1) All aspects of gastrointestinal bleeding, (2) quality assurance and quality review issues in endoscopy and the appropriate use of GI endoscopy, (3) stress ulcer syndrome and (4) gastrointestinal disorders associated with chronic uremia. (5) ischemic colitis. Dr. Zuckerman is listed in “Best Doctors in America 2004” and named in St. Louis Magazine, August 2004, “Best Doctors; Top physicians in the St. Louis area as chosen by their peers.”

“My research activities initially started in the field of liver disease with the development of a radioimmunoassay for hepatitis B antigen subtypes. I subsequently determined epidemiological-clinical correlates of the test in patients with hepatitis B. Since that time my investigative activities mainly have been in the field of clinical gastroenterology and have included evaluating gastrointestinal manifestations of chronic renal failure. My studies in this regard described associations of diverticular disease (I was the first to describe the relationship of polycystic kidney disease to diverticulosis and diverticulitis), nodular duodenitis, and unusual causes of upper gastrointestinal bleeding (initial descriptions of gastric and duodenal angiodysplasia) in patients with various forms of chronic renal disease. My investigative interests now are focused primarily on gastrointestinal bleeding. In a controlled trial of medical therapy for active upper gastrointestinal bleeding, we showed that histamine H2 receptor antagonists were of no value in stopping active bleeding or in preventing rebleeding. We also have examined the value of prophylactic therapy for stress ulcer bleeding and have changed the bleeding definition to be used in other similar trials. We have also developed and utilized a pocket-sized color confirmation card for the purpose of correlating the color of stool blood with the level of gastrointestinal bleeding so that the most appropriate diagnostic algorithms can be determined. I have also investigated occult gastrointestinal bleeding in a study utilizing bidirectional endoscopy in patients with guaiac positive stool, and have written a major review article on lower intestinal bleeding. Along with the intensive care unit, we have developed triage criteria and outcome criteria for gastrointestinal bleeding. My interest in quality assurance issues resulted in a study looking at the occurrence of infectious risk factors associated with endoscopic procedures and at endoscope disinfection methods. I am also the editor of a book on complications of endoscopy. I was also the lead author on a paper that characterized the clinical spectrum and definitions for occult and obscure GI bleeding and a study that discovered an endoscopic finding that appears to be associated with a form of ischemic colitis.”


View Gary R. Zuckerman’s research publications on PubMed »