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DDRCC
Nicholas V. Costrini
Digestive Disease
Research Program
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Research
The Division of Gastroenterology at Washington University School of Medicine is currently working on cutting-edge molecular and translational research. The Division of Gastroenterology has a diverse research base with a number of physician-scientists (MD and MD, PhD) and PhD scientists conducting basic investigation into the molecular regulation of development, nutrient absorption, colon carcinogenesis, immune tolerance and inflammation and repair. In addition, there is a range of active translational research, including novel therapies for inflammatory bowel disease, obesity and energy metabolism, hepatic steatosis, hepatitis C and topographic manometric assessment of esophageal motility.
Laboratories
| Principal Investigator | Research Interests |
| Matthew Ciorba, M.D. | -Inflammatory bowel diseases.
-Indoleamine 2,3 Dioxygenase in Intestinal Inflammation.
-The role of probiotic bacteria in modulating mechanisms of intestinal repair. |
| Nicholas Davidson, M.D. | -The molecular genetics of lipid transport and in the post-transcriptional regulation of gene expression.
-Lipid storage diseases and defects in macronutrient absorption.
-The molecular genetics of colorectal cancer. |
| Brian Dieckgraefe, M.D., Ph.D. | -The study of the cellular signaling pathways and mediators used to sense and respond to epithelial injury.
-The identification of proximate events in the development of Crohn's disease. |
| Dayna S. Early, M.D. | -Understanding barriers to colorectal cancer screening.
-The effect of insulin resistance on the development of colorectal neoplasia.
-The role of selenium on the development of colorectal neoplasia.
-Diagnosis of gastrointestinal cancers. |
| Marc Levin, M.D. | -The molecular basis of the small intestinal adaptive response following loss of small bowel surface area.
-Nutrient modulation of the small intestinal adaptive response.
-The role of retinoids and cellular retinol binding proteins in small intestinal adaptation. |
| Ellen Li, M.D., Ph.D. | -The structure and function of RXR and PPAR.
-The functional role of RXR heterodimers in the GI Tract.
-Inflammatory bowel disease tissue procurement facility. |
| Rodney Newberry, M.D. | -Intestinal inflammatory diseases.
-The incidence of celiac disease among persons with osteoporosis. |
| Deborah Rubin, M.D. | -Identifying the molecular mechanisms underlying intestinal epithelial cell proliferation and differentiation.
-The role of epithelial mesenchymal interactions in inducing the normal morphogenesis and differentiation of the gut mucosa. |
| William Stenson, M.D. | -The role of inflammation in intestinal injury and wound repair. |
| Sandeep Tripathy, M.D., Ph.D. | -Natural Killer (NK) cell development and activation.
-Role of innate immunity in the pathogenesis of gastrointestinal and hepatic diseases. |
Division of Gastroenterology
Department of Medicine
Washington University School of Medicine
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