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The Dr. Nicholas V. Costrini Digestive Disease Research Program at Washington University
I. Statement of Intent This program has been established by Dr. Nicholas V. Costrini (President of the Georgia Gastroenterology Group, Savannah, GA) in gratitude for the training he received as a fellow in Gastroenterology at Washington University School of Medicine. Dr. Costrini intends this to be a ten (10) year continuing grant program that will advance knowledge of inflammatory bowel disease, with emphasis on Crohn's Disease and Ulcerative Colitis. Because there is need to encourage nascent ideas and novel concepts in this field, the Program intends to fund small research proposals from young faculty members. The greatest emphasis will be placed on innovation and soundness of the hypothesis. II. Program DetailsProgram recipients are restricted to any Department/Division of the Faculty of the School of Medicine, and must submit an application in the spring of each year. Strongest consideration will be given to young investigators seeking funds for pilot studies of new or innovative clinical, basic, and/or translational research projects. Genetics, molecular biology, nutrition, natural history, evidence-based outcomes research, and therapeutic applications will be encouraged. Dr. David Alpers will chair the Executive Committee, assisted by Drs. David Kipnis and Jeffrey Gordon. All grants will be submitted for outside review, and the final selection will be made by the Executive Committee. The program recipient will be announced in June of each year, and the award will be given at an awards dinner. Funding will begin July 1 of each year. Program recipients may re-apply for additional support in a following year, but the Program will not give priority consideration to a re-application. III. FundingAwards will be for $25,000, but may not be used for the salary of the P.I. Funds may be used for those items that are part of the approved budget submitted with the project. Program Description Purpose: The major objective of this program is to provide research support to test innovative hypotheses involving idiopathic inflammatory bowel disease (IBD)-related research. This research should involve some aspect of either basic science (e.g. immunology, inflammatory regulation, cell signaling, genetic aspects) or clinical research (e.g. natural history, evidence-based outcomes research, or therapeutic applications in Crohn's disease, ulcerative colitis, or microscopic colitis). We also hope this program will encourage young investigators and more established investigators in other fields to approach problems which are relevant to our understanding of small bowel and colonic response to inflammation in idiopathic IBD and increase our understanding of the prevention, etiology, pathophysiology, and therapy of these diseases. In addition, it is hoped that a Costrini IBD Research Award will generate enough preliminary data for the investigator to obtain research funding by conventional mechanisms (e.g., RO1). Who is Eligible? Junior full-time faculty at Washington University including:
Applicants must be U.S. citizens or have a permanent visa, hold a Ph.D., M.D., or equivalent degree, and have at least 2 years of recent relevant research experience. We are especially interested in faculty members who are within 8 years of their first faculty appointment. Deadline and Review Process: Applications must be submitted for review by 4:00 p.m. on Monday, March 20, 2006. Awards will be announced by June 1, 2006 and funding will start July 1, 2006. All applications will be reviewed by the Internal and External Advisory Committee members for scientific merit, originality, relevance of the work to IBD, the potential for the project to generate data for a successful peer-reviewed grant application, and the potential for the PI to develop into an independent investigator. Awards: The Nicholas V. Costrini Digestive Disease Research Program will fund one award for $25,000 for one year. Although a second year of funding may be possible, the Program favors funding a new project each year. All applications must have appropriate institutional regulatory approvals (Human Studies Committee (HSC), Animal Studies, etc). Terms of Awards: Grantees will be required to submit to the Executive Committee of the program (Drs. David Alpers, David Kipnis, Jeffrey Gordon) a brief annual progress report describing the results of their work, as well as related publications and funding. If applying for a second year of funding, a full progress report on NIH 398 form is required. All publications should acknowledge the Nicholas V. Costrini Digestive Disease Research Program at Washington University. It is expected that the Grantee will use the full amount of funding awarded during each one-year term of the award. However, unexpended funds at the end of the term can be rolled over into subsequent years. Extensions or changes to the terms of the award (length of funding period and budget) will only be made in exceptional circumstances. Annual review: The recipient will receive the award from Dr. Costrini at a dinner given to honor the current and past recipients. At the end of the funding year, the grantee will be expected to present a research seminar in the Division of Gastroenterology summarizing progress towards the scientific objectives of the proposal. When possible, this special seminar and the award dinner will occur on the same day. Completed original application, 5 copies, and an electronic file (on disk or as e-mail attachment) should be submitted to: Madhvi Jayarao, Nicholas V. Costrini Digestive Disease Research Program AdministratorGastroenterology Campus Box 8124
Phone: 362-9050
Instructions Applications are due on Monday, March 20, 2006.
Additional Instructions:
1. Please list the Principal Investigator's (PI) name on the top right-hand corner of every page of the application. 2. When completing the budget page, please refer to the list of expenditures allowed and not allowed included with these instructions. 3. The following headings should be used for the research plan (A-D maximum 4 pages).
B. Background and Significance: State the relevance of the proposed project to basic, clinical or prevention and control. C. Preliminary Studies/Progress Report: Discuss the pertinent research findings that will help to establish the experience and competence of the investigator. D. Research Design and Methods: Concisely present your experimental design and the methods to be used to accomplish your specific aims relating to that of IBD and to longer term funding objectives. Also indicate how the results will be interpreted, how plans would be modified by unexpected results, and how they will lead to future investigations. Well-known methods and standard procedures may be described very briefly or referenced, but novel experimental approaches should be outlined in more detail. Allocation and Expenditure of Funds:
Expenditures Allowed:
Division of Gastroenterology
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