Samuel Klein, M.D.

Samuel Klein, M.D.

William H. Danforth Professor of Medicine and Nutritional Science

Office Location: 201 West Building
Telephone: (314) 362-8699
Fax: (314) 362-8230
E-mail address:

Dr. Klein joined the Gastroenterology Division in 1994. He received his M.D. degree from Temple University Medical School and subsequently obtained a master's degree in nutritional biochemistry and metabolism from the Massachusetts Institute of Technology. Dr. Klein completed his internship and residency training in internal medicine and a clinical fellowship in nutrition at University Hospital in Boston. Additional training included a research fellowship in nutrition and metabolism at Harvard Medical School and a gastroenterology fellowship at The Mount Sinai Hospital in New York. His research interests involve the use of stable isotope tracers to evaluate substrate metabolism in humans. Dr. Klein's clinical interests are in the areas of short bowel syndrome, obesity, and enteral and parenteral nutrition support.

Research Interests

“My research activities involve the use of stable isotope tracers and mass spectrometry methodology to evaluate substrate metabolism in vivo in humans. My laboratory has been interested in several areas: 1) the factors that regulate the mobilization of adipose tissue triglyceride during physiological conditions that require body fat as a fuel, such as starvation and endurance exercise; 2) the effect of aging on substrate mobilization and oxidation; and 3) the alterations in lipid kinetics in obese persons and the effect of weight loss and exercise training on whole body and cellular lipid metabolism.”

Link to Medline for selected publications

Division of Gastroenterology
Department of Medicine
Washington University School of Medicine