Sreenivasa Jonnalagadda, M.D.

Sreenivasa Jonnalagadda, M.D.

Professor of Medicine

Director, Biliary and Pancreatic Endoscopy

Dr. Jonnalagadda is the Director of Biliary and Pancreatic Endoscopy. After graduating from Goa Medical College, India, he completed a residency in internal medicine at Saint Louis University School of Medicine and a fellowship in Gastroenterology and Hepatology at the University of Missouri-Kansas City. He gained further endoscopic experience as an advanced clinical fellow at the renowned Center for Therapeutic Endoscopy and Endoscopic Oncology, Wellesley Hospital, University of Toronto, Canada. He was recruited in 1999 to join the Interventional Endoscopy Section and the Division of Gastroenterology at the Washington University School of Medicine. He has been directing the Biliary and Pancreatic endoscopy program at Barnes-Jewish Hospital and Washington University School of Medicine since January 2008.

Areas of clinical and research interest include biliary and pancreatic endoscopy, sphincter of Oddi dysfunction, sampling techniques in biliary malignancies, endoscopic palliation of malignancy, sedation for endoscopic procedures, endoscopic therapy of large colon polyps, role of newer imaging techniques such as cholangioscopy in patient management. Dr. Jonnalagadda is also interested in the expanding frontiers of endoscopy, such as endoscopic therapies for gastroesophageal reflux disease and obesity. The first TransOral Gastroplasty (TOGA) procedure in United States was performed at the Washington University School of Medicine by Dr. Jonnalagadda in 2008.

Dr. Jonnalagadda has directed the annual Saint Louis Live Therapeutic Endoscopy Course since it was initiated in 2007. This endoscopy course features live transmission of advanced endoscopic procedures from the Center of Advanced Medicine to the EPNEC Center with participation of nationally renowned experts within the field of endoscopy. This course is held in conjunction with the Fellows Advanced Endoscopy Program. He is also active in the scientific and educational mission of the American Society of Gastrointestinal Endoscopy.

"The integration of various endoscopic and radiologic modalities to image the biliary tree and pancreas, endoscopic palliation of gastrointestinal malignancy and emerging technologies that expand the frontiers of endoscopy are areas of interest to me."

 

Select Publications

  1. Huang SC, Talkad VD, Fortune KP, Jonnalagadda S, Severi C, Fave GD, Gardner JD.  Modulation of cholecystokinin activity by albumin.  Proc Natl Acad Sci 1995; 92:10312-10316.
  2. Jonnalagadda S, Quiason S, Smith O.  Successful therapy of bleeding duodenal varices by TIPS following failure of sclerotherapy.  Am J Gastroenterol 1998; 93(2):272-274.
  3. Clarkston WK, Kuganeswaran E, Jonnalagadda SS, Smith OJ.  Iatrogenic esophageal foreign body and extrinsic tracheal compression during esophageal band ligation.  Gastrointest Endosc 1998;47(1):106-107
  4. Kuganeswaran E, Clarkston WK, Cuddy PG, Quiason SG, Pandya PK, Dierenfeldt WT, Jonnalagadda SS, Smith OJ, Chen ST.  A double-blind placebo controlled trial of oral midazolam as premedication before flexible sigmoidoscopy.  Am J Gastroenterol 1999;94(11):3215-3219.
  5. Murty CV, Prabhakar YV, Rao VB, Jonnalagadda SS. Drug-resistant falciparum malaria with bowel symptoms. Am J Gastroenterol 2000;95(4):1101
  6. Agrawal S, Jonnalagadda S.  Gallstones, from gallbladder to gut. Management options for diverse complications. Postgrad Med 2000;108(3):143-153.
  7. Trivedi M, Zafar S, Spalding MJ, Jonnalagadda S. Ornithine transcarbamylase deficiency unmasked because of gastrointestinal bleeding.  J Clin Gastroenterol 2001;32(4):340-343
  8. Husain A, Diebold C, Edmundowicz SA, Jonnalagadda SS.  New Technique: Directed balloon-assisted guide wire access of intrahepatic ducts. Gastrointest Endosc 2001;54 (1):118-119.
  9. Lin A, Jonnalagadda S, Edmundowicz SA.  Diagnosis of Malignant Biliary Strictures.  Techniques in Gastrointest Endosc 2002;4(3):102-112
  10. Jonnalagadda S. And now fattening the lower esophageal sphincter. Gastroenterology 2002;123(3):944-946.
  11. Jonnalagadda S, Prakash C.  Intestinal Strictures can Impede Wireless Capsule Endoscopy.  Gastrointest Endosc 2003; 57(3):481.
  12. Jonnalagadda S.  Virtual Colonography—A Step Forward? Gastroenterology 2003; 124(1):258-259.
  13. Jonnalagadda S. Small bowel photography: The jury needs more evidence. Gastroenterology 2003;124:1148-1156.
  14. Jonnalagadda S. Cholecystectomy after treatment of choledocholithiasis – on firmer ground. Gastroenterology 2003;125:617-618.
  15. Jonnalagadda S. Prophylactic pancreatic duct stenting-a panacea? Gastroenterology 2003;125(4):1274-1275.
  16. Jonnalagadda S. Anti-reflux surgery for Barrett’s esophagus? Gastroenterology
    2004;126(2):610-611.
  17. Jonnalagadda S, Shiels A, Clouse RE. Intravenous proton pump inhibitors: requiem for endoscopic therapy? Gastroenterology  2004;126(4):1207-1209.
  18. Jonnalagadda SS, McFarland E.  Virtual colonoscopy – finally a credible contender. Gastroenterology 2004;126(7)1910-1911.
  19. Jonnalagadda S. Improving prognosis in pancreatic cancer – an uphill endeavor. Gastroenterology 2004;127(5):1636-1637.
  20. Jonnalagadda S. Ampullary adenomas: Maturing management strategies. Gastroenterology 2005;128(1):236-238.
  21. Janec E, Jonnalagadda S. Sacral spinal nerve stimulation for faecal incontinence – A viable therapeutic option for refractory incontinence. Gastroenterology 2005;129(1):388-389.
  22. Shah R, Jonnalagadda S. The gist of a stromal tumor. Gastroenterology 2005;128(7):2170-2171.
  23. Lisker-Melman M, Jonnalagadda S. Swimming in cloudy waters: Efforts to prevent HCV-related HCC. Gastroenterology 2005;129(5):1794-1796.
  24. Jonnalagadda S. New frontier in wireless endoscopy: Crohn’s disease. Gastroenterology 2006;130(2):615-616.
  25. Oh YS, Edmundowicz SA, Jonnalagadda SS, Azar RR.  Pancreaticopleural fistula: report of two cases and review of the literature. Dig Dis Sci 2006;51(1):1-6.
  26. Azar RR, Oh YS, Janec EM, Early DS, Jonnalagadda SS, Edmundowicz SA. Wire-guided pancreatic pseudocyst drainage by using a modified needle knife and therapeutic echoendoscope.  Gastrointest Endosc 2006;63(4): 688-692.
  27. Jonnalagadda S. Exercising caution during placement of wireless pH monitoring capsule. Gastrointest Endosc 2006;63(4):734.
  28. Jonnalagadda S. Double Balloon Enteroscopy: Wired technology meets wireless. Gastroenterology 2006;131(1):327-329.
  29. Jonnalagadda S, Prakash C.  Esophageal Impedance Testing: Unraveling The Mysteries of Gastroesophageal Reflux.  Gastroenterology 2006;131(1):322-323.
  30. Prakash C, Jonnalagadda S, Azar R, Clouse RE.  Endoscopic removal of the wireless pH monitoring capsule in patients with severe discomfort. Gastrointest Endosc. 2006; 64(5):828-832.
  31. Peifer KJ, Shiels AJ, Azar R, Rivera RE, Eagon JC, Jonnalagadda S.  Successful endoscopic management of gastrojejunal anastomotic strictures after Roux-en-Y gastric bypass. Gastrointest Endosc. 2007; 66:248-252.
  32. Ringold D, Jonnalagadda S. Complications of Therapeutic Endoscopy: A Review of the Incidence, Risk Factors, Prevention, and Endoscopic Management. Techniques in Gastrointest Endosc. 2007; 9(2):90-103.
  33. Kerr TA, Jonnalagadda S, Prakash C, Azar R. Pancreatitis following Olanzapine Therapy: A Report of Three Cases.  Case Rep Gastroenterol 2007;1:15-20.
  34. Maple JT, Peifer KJ, Edmundowicz, SA, Early DS, Meyers BF, Jonnalagadda S, Azar RR.  The impact of endoscopic ultrasonography with fine needle aspiration (EUS-FNA) on esophageal cancer staging: a survey of thoracic surgeons and gastroenterologists.  Diseases of the Esophagus 2008;21(6):480-487.
  35. Pierce RA, Jonnalagadda S, Spitler JA, Tessier DJ, Liaw JM, Lall SC, Melman LM, Frisella MM, Todt LM, Brunt LM, Halpin VJ, Eagon JC, Edmundowicz SA, Matthews BD.  Incidence of residual choledocholithiasis detected by intraoperative cholangiography at the time of laparoscopic cholecystectomy in patients having undergone preoperative ERCP. Surg Endosc . Accepted January 2008. http://dx.doi.org/10.1007/s00464-008-9785-3.
  36. Jonnalagadda SS, Azar R. Avoiding pneumomediastinum during ERCP after percutaneous transhepatic biliary drainage. Gastrointest Endosc. 2008. Accepted, in press.
  37. Maple J, Keswani R, Edmundowicz S, Jonnalagaddda S Azar R,. Wire-assisted access sphincterotomy of the minor papilla. Gastrointest Endosc. 2009 Jan;69(1):47-54
  38. Sikka S, Ringold D, Jonnalagadda S, Banerjee B. Comparison of White Light and Narrow Band High Definition Images in Predicting Colon Polyp Histology Using Standard Colonoscopes. Endoscopy. 2008 Oct;40(10):818-22.
  39. Melman L, Azar R, Beddow K, Brunt LM, Halpin VJ, Eagon JC, Frisella MM, Edmundowicz S, Jonnalagadda S, Matthews BD.  Primary and overall success rates for clinical outcomes after laparoscopic, endoscopic, and open pancreatic cystgastrostomy for pancreatic pseudocysts. Surg Endosc. 2009 Feb;23(2):267-71.
  40. Nguyen Y, Maple J, Zheng Q, Ylagan LR, Zhai J, Kohlmeier C, Jonnalagadda SS, Early DS, Edmundowicz SA, Azar RR. The reliability of gross visual assessment of specimen adequacy during EUS-FNA of pancreatic masses. Gastrointest Endosc August 2008. Accepted, in press.
  41. Keswani R, Ammar T, Azar RA, Edmundowicz SA, Early D, Jonnalagadda SS. Stenting for Malignant Colonic Obstruction: A Comparison of Efficacy and Complications in Colonic versus Extracolonic Malignancy. Gastrointest Endosc. 2008. Accepted, in press.
  42. Cote GA, Azar RR, Edmundowicz SE, Jonnalagadda SS. Balloon-assisted peroral cholangioscopy using an 8.8mm gastroscope for the diagnosis of Mirizzi syndrome. Gastrointest Endosc (in press).
  43. Maple JT, Keswani RN, Hovis RM, Saddedin EZ, Jonnalagadda S, Azar RR, Hagen C, Thompson DM, Waldbaum L, Edmundowicz SA.  Carbon dioxide (CO2) insufflation during ERCP for the reduction of post-procedure pain: a randomized, double-blind controlled trial.  Gastrointest Endosc.  (in press).

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Link to Interventional Endoscopy Program

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Division of Gastroenterology
Department of Medicine
Washington University School of Medicine